Liposomal formulation of vitamin A for the potential treatment of osteoporosis

Abstract

Vitamin A targeting to bones is a suitable treatment for osteoporosis. In this study, we have developed vitamin A-encapsulated liposomes that can be useful to deliver vitamin A to the bones in a selective manner. This liposomal formulation of vitamin A has been found to be stable for >6 months as no significant change in size and charge occurred. Vitamin A liposomes-induced cell proliferation in SaOS-2 (human osteosarcoma cell line) and release kinetics study concluded that the liposomal formulation of vitamin A gives a controlled release of vitamin A in comparison to the free vitamin. The MTT assay showed the proliferation of SaOS-2 cells after their treatment with vitamin A liposomes.