Evolution: Paralog interference stabilizes gene duplicates

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dc.contributor.authorSwamy, Krishna B.S.
dc.date.accessioned2026-04-27T04:12:54Z
dc.date.available2026-04-27T04:12:54Z
dc.date.issued2026-03
dc.description.abstractGene duplicates are traditionally viewed as evolutionarily unstable, as one copy can freely accumulate deleterious mutations and be lost. A new study reveals that paralog interference exposes certain mutations to purifying selection, prolonging the survival of duplicates and increasing their chances of functional divergence and long-term retention in the genome. © 2026 Elsevier Inc.
dc.identifier.citationSwamy, Krishna B.S., & Leu, J.-Y. (2026). Evolution: Paralog interference stabilizes gene duplicates. Current Biology, 36(6), R261–R264. Scopus. https://doi.org/10.1016/j.cub.2026.02.015
dc.identifier.doihttps://www.sciencedirect.com/science/article/abs/pii/S096098222600165X?via%3Dihub
dc.identifier.issn0960-9822
dc.identifier.issn1879-0445
dc.identifier.urihttps://ir.ahduni.edu.in/handle/123456789/6662
dc.language.isoen
dc.publisherCell Press
dc.schoolSchool of Arts and Sciences
dc.sourceCurrent Biology
dc.subjectAnimals
dc.subjectEvolution, Molecular
dc.subjectGene Duplication
dc.subjectGenes, Duplicate
dc.subjectMutation
dc.subjectSelection, Genetic
dc.titleEvolution: Paralog interference stabilizes gene duplicates
dc.typeJournal Article

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